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ANTIBODY ENGINEERING
The role and importance of recombinant human monoclonal antibodies for therapeutics has seen an increase in the number of antibodies going into clinical trials in the last 5 years. The lab applies phage display for the identification of novel human monoclonal antibodies against a diverse set of target antigens. The current focus of the lab is mainly on infectious diseases with the development of several immune antibody libraries. The lab has also developed several other naïve and synthetic antibody libraries for application. The libraries have since been used to develop a panel of different antibodies against several infectious disease biomarkers. Together with several other collaborators, the lab is also working to generate monoclonal antibodies against other diseases. It is our goal to develop antibodies that can be developed for therapeutic and diagnostic applications.
DNA TECHNOLOGY
DNA is the fundamental building block of life, where all the genetic information of a living organism is stored. In addition to that, DNA possesses unique and interesting characteristics that are capable of mediating many other functions in life. The understanding of DNA mechanistic has allowed the development of novel applications surrounding DNA mainly self assembly technologies. Manipulation of DNA is now possible for the purpose of nanostructure formation, logic gate systems and sensing applications. The laboratory is currently pioneering methods to integrate both recombinant antibody technology with DNA nanotechnology for biomedical applications.
BIOSENSOR TECHNOLOGY
The need for cheaper alternative sensing platforms especially for application in low-resource settings is a growing challenge. We are interested to look into alternative sensing platforms that are derived by using cheaper materials as well as molecular based modifications of biomolecules (antibodies and DNA) to fit in these alternative platforms. Cheaper materials such as paper and plastics are interesting materials that we look to adapt for the development of sensor platforms for diagnostic applications.
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