Our Research Interests
The group's focus is on the utilization of antibody phage display technology to generate antibodies against targets including toxins, cancer markers, viral proteins and etc. We are interested to study the gene segment usage of naive and immune antibody repertoires for antibody designs. The group is also actively invovled in developing immune antibody libraries for infectious diseases. We also utilize our naive libraries to develop novel antibodies for diagnostic and therapeutic applications. We also look at engineering antibodies to fine tune the functional properties and customise desired characteristics of human antibodies.
The group also looks into molecular methods to innitiate mutagenesis for directed evolution experiments. DNA technology is also another focus area of the lab where development of DNA biosensors and utilisation of DNA nanostructures. This mainly invovles the use of DNAzymes as reporter systems for DNA sensing. The aim is to bridge both antibodies and DNA for various biomedical applications. These molecules are then adapted to novel platforms for sensing applications.
RESEARCH VACANCIES
Project Title
Antibody development and engineering for improved characteristics
Project Description
Antibodies are useful biomolecules for various applications. The design, development and engineering of antibodies to produce specific characteristics is a major challenge in bio-drug development. In this project, you will be involved in the design and development of novel antibodies for various target molecules. You will also carry out design modification to generate antibodies with improved characteristics using molecular methods. The candidate would be required to learn basic programming skills for data analysis.
Vacancies for
Multiple vacancies for PhD and MSc by research
*To apply or enquire, please write to Assoc. Prof. Dr. Lim Theam Soon